Skip to main content
VitalDecades logo VitalDecades

Pillar / Weight and metabolism

Weight and metabolism

GLP-1 medications, what they cost, who prescribes them online, and the metabolic numbers that decide whether any of it is working. Every price is dated, every program is checked against the FDA record, and every threshold is tied to the guideline that sets it.

6 guides · last checked

A woman in a plaid shirt preparing vegetables in a kitchen, with a bowl of fruit in the foreground.
Photo: Pavel Danilyuk / Pexels

01  /  Start here

Guides, newest first

02  /  What we recommend

Services we have checked

We include products and services we think are useful. If you buy through links on this page, we may earn a commission. Here is how we pick.

Telehealth / primary care

4.0

Sesame

Best for uninsured or high-deductible readers who want an upfront price for a visit, or a lower-fee brand-only GLP-1 program.

Sesame is the honest budget option: transparent per-visit cash prices, clinicians in every state, and a weight-loss program that sells brand-name GLP-1s only. It does not bill insurance, so insured readers pay out of pocket for the visit.

Telehealth visits from $34; weight-loss program $99/mo or $59/mo annual

Read our review See visit prices

Weight management / GLP-1

3.3

Trimi

Best for cash payers set on a compounded GLP-1 who will prepay a longer plan and accept that these are not FDA-approved products.

Trimi undercuts every compounded program we checked ($99 to $175 a month for semaglutide) and names its prescriber network and pharmacies. Its own terms never name a legal entity, and one cited pharmacy licence resolves to a different company name. Good price, read the fine print.

Compounded semaglutide from $99/mo on a 12-month prepay; $175 month to month

Read our review See plans

Weight management / GLP-1

2.6

SHED

Best for cash payers who have decided on a compounded GLP-1, understand it is not an FDA-approved product, and are comfortable with a two-month minimum.

SHED sells compounded semaglutide from $159 to $199 a month and brand-name options through a separate membership. The prices are real; so are the two-month minimum, the non-refundable fees, and a BBB complaint pattern about billing without shipment. Read the terms before you buy.

Compounded semaglutide from $159/mo on a 12-month plan; brand Wegovy and Zepbound at pharmacy price

Read our review Check eligibility

03  /  Numbers to track

Biomarkers that matter here

Apolipoprotein B

ApoB

Risk-enhancing factor: 130 or higher mg/dL

Fasting plasma glucose

FPG

Normal (below the prediabetes range): under 100 mg/dL

HDL cholesterol

HDL-C

Low (a major risk factor): under 40 mg/dL

Hemoglobin A1C

A1C

Normal (below the prediabetes range): under 5.7 %

High-sensitivity C-reactive protein

hs-CRP

Low relative risk: under 1 mg/L

LDL cholesterol

LDL-C

Optimal: under 100 mg/dL

Triglycerides

TG

Normal: under 150 mg/dL