Choose your path
Every option over 12 months
Medication cost only; add program fees from the table below if you need online prescribing. Ranges reflect dose-dependent pricing.
| Option | Total, 12 mo | Per month | Notes |
|---|---|---|---|
|
Wegovy pen (brand, self-pay) NovoCare Pharmacy · 2026-08-19 |
$3,888–$4,388 | $324–$366 | $199/mo for the first two months (new patients), then $349, or $399 for Wegovy HD. |
|
Wegovy tablets (brand, self-pay) NovoCare Pharmacy · 2026-08-19 |
$1,788–$3,588 | $149–$299 | $149 to $299/mo depending on dose. |
|
Zepbound (brand, self-pay) LillyDirect · 2026-08-19 |
$5,188 | $432 | $299 (2.5 mg) month one, $399 (5 mg) month two, then $449 for 7.5 to 15 mg refilled within 45 days; a late refill reprices to $499 to $699. |
|
Foundayo (brand, self-pay) LillyDirect · 2026-08-19 |
$1,788–$3,588 | $149–$299 | $149 to $299/mo depending on dose. |
|
Compounded semaglutide, Trimi (all-in) Trimi · 2026-08-19 |
$1,188–$2,100 | $99–$175 | $175 month to month down to $99/mo on a 12-month prepay; prescribing included. Not an FDA-approved product. |
|
Compounded semaglutide, Shed (all-in) Shed · 2026-08-19 |
$1,908–$2,388 | $159–$199 | $199/mo month to month down to $159/mo on a 12-month term; two-month minimum. Not an FDA-approved product. |
Program fees, if you want online prescribing
A program writes the prescription and handles insurance paperwork; the medication above is still billed separately on brand paths.
| Program | Fee schedule |
|---|---|
| Ro Body, month to month | $39 first month (refunded if not eligible), then $149/mo. |
| Ro Body, annual prepay | $39 first month, then the $74/mo rate that requires a prepaid annual plan. |
| Sesame weight-loss program, monthly | $99/mo; brand medication only. |
| Sesame weight-loss program, annual rate | $59/mo on an annual plan; brand medication only. |
We have reviewed these programs: Everlywell, Ro Body, Sesame, SHED, Trimi. Side by side: the ranked comparison.
What this calculator does not know
Insurance. With commercial coverage and a manufacturer savings card, brand GLP-1s can drop to $25 a month; Medicare Part D still cannot cover drugs used solely for weight loss. Our coverage guide walks through it. Prices here are the sellers' posted self-pay rates on the date shown; they change, and we re-check them when we update this page.