We include products and services we think are useful. If you buy through links on this page, we may earn a commission. Here is how we pick.
01 Top pick
4.4/5
Ro Body
Weight management / GLP-1
Ro Body is the strongest pick when you want a brand-name GLP-1 and someone to fight your insurer for coverage; the membership fee is the thing to watch once the $39 first month ends.
Best for People with insurance who want prior authorization handled, or cash payers who want Wegovy, Zepbound or Foundayo at manufacturer prices.
- FDA-approved medications only: Wegovy (pen and pill), Zepbound, Foundayo
- Insurance concierge files prior authorization for you
- All 50 states and DC; $39 first month refunded if not eligible
Pricing
As of 2026-08-19: $39 first month, then $74 to $149/mo membership; medication extra at LillyDirect/NovoCare cash prices.
02
4.0/5
Telehealth / primary care
Sesame is the honest budget option: transparent per-visit cash prices, clinicians in every state, and a weight-loss program that sells brand-name GLP-1s only. It does not bill insurance, so insured readers pay out of pocket for the visit.
Best for Uninsured or high-deductible readers who want an upfront price for a visit, or a lower-fee brand-only GLP-1 program.
- Cash price shown before you book; no membership required
- Licensed clinicians, video and in-person, all 50 states
- Weight-loss program sells FDA-approved GLP-1s only
Pricing
As of 2026-08-19: telehealth visits from $34; weight-loss program $99/mo or $59/mo on an annual plan; medication extra; Sesame Plus $10.99/mo.
03
3.3/5
Weight management / GLP-1
Trimi undercuts every compounded program we checked ($99 to $175 a month for semaglutide) and names its prescriber network and pharmacies. Its own terms never name a legal entity, and one cited pharmacy licence resolves to a different company name. Good price, read the fine print.
Best for Cash payers set on a compounded GLP-1 who will prepay a longer plan and accept that these are not FDA-approved products.
- One flat price at every dose: $175 monthly down to $99 on a 12-month prepay
- Names its prescriber network (Arora Health) and its compounding pharmacies
- Async intake reviewed within 24 hours; ships in 3-month supplies
Pricing
As of 2026-08-19: compounded semaglutide $175/mo monthly, $145 (3 mo), $120 (6 mo), $99 (12 mo prepaid); tirzepatide $235 / $199 / $175 / $125.
Sells compounded semaglutide and tirzepatide, which are not FDA-approved products.
Visit Trimi Read our review04
2.6/5
Weight management / GLP-1
SHED sells compounded semaglutide from $159 to $199 a month and brand-name options through a separate membership. The prices are real; so are the two-month minimum, the non-refundable fees, and a BBB complaint pattern about billing without shipment. Read the terms before you buy.
Best for Cash payers who have decided on a compounded GLP-1, understand it is not an FDA-approved product, and are comfortable with a two-month minimum.
- Brand Wegovy and Zepbound available alongside compounded
- Semaglutide $199, $179 or $159/mo by term; tirzepatide from $239
- Two-month minimum; fees non-refundable once charged
Pricing
As of 2026-08-19: compounded semaglutide $199/mo (1 mo), $179 (6 mo), $159 (12 mo); tirzepatide $299 / $269 / $239; brand Wegovy or Zepbound via a $125/mo membership plus medication.
Sells compounded semaglutide and tirzepatide, which are not FDA-approved products.
Visit SHED Read our reviewHow we chose and ranked
Every program was read on 2026-08-19: pricing, product, safety and terms pages. Each was checked against the FDA warning-letter database (including the telehealth warning-letter waves of September 2025, February 2026 and June 2026), FDA import alerts, FTC and state attorney-general actions, and federal court dockets. Scores are the average of five metrics printed on each review: price transparency, prescriber process, product disclosure, refunds and cancellation, and insurance support. Rankings do not consider what a program pays us; that figure is disclosed on the review page and on our how-we-pick page.
Who we did not include, and why
Hims. Hims & Hers Health, Inc. received an FDA warning letter on 2025-09-09 for marketing compounded semaglutide with claims the FDA found false or misleading (misbranded under the FDCA), was named in an FDA Commissioner statement on 2026-02-06 about companies mass-marketing non-FDA-approved GLP-1s, and is the defendant in a suit filed 2026-07-29 by the FTC, the Utah Attorney General and Los Angeles County alleging that it shared sensitive health data with advertising platforms and used deceptive billing and cancellation practices. Its storefront now sells brand-name GLP-1s only, and the case is pending, not decided. Under our rule, a partner with a standing FDA warning letter is not eligible for this list.
HealthRx. Sells compounded semaglutide and tirzepatide at low flat prices and carries no FDA actions, but publishes no operating legal entity, postal address, named pharmacy or medical group anywhere on its site, and labels its homepage testimonials as illustrative composites. We could not complete the state-board part of the check because there is no entity to check. It stays off the list until that changes.
How to choose
If you have insurance that might cover a GLP-1, start with Ro Body: its concierge does the prior authorization. If you are paying cash and want a brand-name product with a lower monthly fee, Sesame's program is $59 to $99 a month plus medication at manufacturer prices. If you have decided on a compounded product, Trimi is the cheapest we found and lets you cancel before the prescription is issued, but publishes no legal entity; SHED costs more and has stricter terms but names its company. Either way, understand that compounded semaglutide and tirzepatide are not FDA-approved products.
Frequently asked questions
What is the cheapest way to get a GLP-1 online? ▼
Compounded programs advertise the lowest monthly numbers ($99 to $175 for semaglutide at Trimi and $159 to $199 at SHED, as of 2026-08-19), but they sell products the FDA has not reviewed. Among brand-only programs, Sesame's program fee is lower than Ro's; the medication itself costs the same manufacturer cash price either way ($149 to $699 a month depending on drug and dose).
Do any of these take insurance? ▼
Ro Body checks coverage and files prior authorization for brand medications. Sesame does not bill insurance but its providers can help with paperwork. SHED states insurance may not be accepted.
Are compounded GLP-1s safe? ▼
They are prescription products made by pharmacies under a clinician's order and are not reviewed by the FDA for safety, effectiveness or quality. The FDA has warned about them repeatedly since 2025. Talk with your own clinician before choosing one.
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